Clinical Trials Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2016; 22(43): 9595-9603
Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9595
Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux
Nuray Uslu Kızılkan, Murat Fani Bozkurt, Inci Nur Saltık Temizel, Hülya Demir, Aysel Yüce, Biray Caner, Hasan Özen
Nuray Uslu Kızılkan, Division of Pediatric Gastroenterology, Koc University Hospital, Topkapı, Istanbul 34010, Turkey
Murat Fani Bozkurt, Biray Caner, Hacettepe University Faculty of Medicine, Department of Nuclear Medicine, Ankara 06100, Turkey
Inci Nur Saltık Temizel, Hülya Demir, Aysel Yüce, Hasan Özen, Division of Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
Author contributions: Uslu Kızılkan N acquired the data, conducted the pH and impedance studies, contributed to the data analysis, and drafted the manuscript; Bozkurt MF and Caner B conducted the scintigraphic studies and analysis; Saltık Temizel IN, Demir H and Yüce A acquired the data; Özen H conceived and designed the project, conducted the pH and impedance studies, analyzed the data, and edited the manuscript.
Supported by the Scientific and Technological Research Council of Turkey, No. 106S191- SBAG-3439.
Institutional review board statement: This clinical study was reviewed and approved by Hacettepe University Clinical Researches Ethics Board (03.03.2006; B.30.2.HAC.0.01.00.05/222).
Clinical trial registration statement: This registration policy applies to prospective, randomized, controlled trials only.
Informed consent statement: Informed written consent was acquired from all participants or their legal guardian prior to study enrollment.
Conflict-of-interest statement: There are no potential conflicts of interest for any of the authors.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hasan Özen, MD, Division of Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Hacettepe, Ankara 06100, Turkey. haozen@hacettepe.edu.tr
Telephone: +90-312-3051993 Fax: +90-312-3118226
Received: August 12, 2016
Peer-review started: August 19, 2016
First decision: September 14, 2016
Revised: September 27, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: November 21, 2016
Processing time: 97 Days and 16.3 Hours
Core Tip

Core tip: Gastroesophageal reflux (GER) is usually physiological, common in childhood and defined as GER disease (GERD) when it causes troublesome symptoms and/or complications. Unfortunately, the ideal diagnostic method for GERD has not been identified yet. Each method has its own advantages and disadvantages. This study aimed to evaluate the agreement of multichannel intraluminal impedance-pH monitoring and gastroesophageal reflux scintigraphy, which is used frequently all over the world for the diagnosis of GERD. No or slight agreement between tests was found. New diagnostic standards for scintigraphy in GERD should be defined.