Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2016; 22(43): 9571-9585
Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9571
Diabetes mellitus may affect the long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after liver transplantation
Qing Zhang, Yong-Lin Deng, Chang Liu, Li-Hong Huang, Lei Shang, Xin-Guo Chen, Le-Tian Wang, Jin-Zan Du, Ying Wang, Pei-Xiao Wang, Hui Zhang, Zhong-Yang Shen
Qing Zhang, Li-Hong Huang, Xin-Guo Chen, Jin-Zan Du, Ying Wang, Pei-Xiao Wang, Zhong-Yang Shen, Le-Tian Wan, Institute of Liver Transplantation, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
Yong-Lin Deng, Zhong-Yang Shen, Department of Transplant Surgery, Tianjin First Central Hospital, Tianjin 300192, China
Chang Liu, Department of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Lei Shang, Department of Health Statistics, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Hui Zhang, Department of Gastroenterology, Luoyang Dongfang Hospital, Luoyang 471003, Henan Province, China
Author contributions: Zhang Q, Deng YL, Liu C, Huang LH and Shang L contributed equally to this study; Zhang Q and Shen ZY proposed and designed the study; Zhang Q, Deng YL, Liu C and Huang LH performed the research and wrote the first draft of the manuscript; Huang LH, Shang L, Chen XG and Wang LT collected the patient and statistical data; Shang L analyzed and reviewed the data; All authors contributed to the design, revisions and interpretation of the study and to further drafts of the manuscript; Shang L and Shen ZY are the guarantors; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, General Program, No. 81372595; and the National High Technology Research and Development Program of China (863 Program), No. 2012AA021006.
Institutional review board statement: This study was performed in compliance with the principles of the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of the General Hospital of the Chinese People’s Armed Police Force, Tianjin First Central Hospital and the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University (China). Written informed consent was obtained from individual participants.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Zhong-Yang Shen, Institute of Liver Transplantation, General Hospital of Chinese People’s Armed Police Forces, 69 Yongding Road, Haidian District, Beijing 100039, China. zqy47@sina.com
Telephone: +86-10-57976839 Fax: +86-10-68242910
Received: June 11, 2016
Peer-review started: June 17, 2016
First decision: July 12, 2016
Revised: August 2, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: November 21, 2016
Core Tip

Core tip: Diabetes mellitus (DM) may be associated with hepatocellular carcinoma (HCC) pathological features, old age and poor liver function, which may influence post-liver transplantation (LT) survival in hepatitis B virus (HBV)-related HCC patients. However, no direct relation between DM and HBV infection or HBV load were observed in HCC patients. The current data represent a multi-center study involving a larger number of samples, and suggest that DM may affect the long-term post-LT survival of HBV-related HCC patients, but not of tumor recurrence. Thus, HCC patients with DM undergoing LT should be closely followed to optimize outcomes. Follow-up examinations are especially important among DM patients who are elderly or who have the presence of vascular invasion and serum α-fetoprotein levels > 2000 ng/mL pre-LT.