Rademacher C, Bechtler M, Schneider S, Hartmann B, Striegel J, Jakobs R. Self-expanding metal stents for the palliation of malignant gastric outlet obstruction in patients with peritoneal carcinomatosis. World J Gastroenterol 2016; 22(43): 9554-9561 [PMID: 27920476 DOI: 10.3748/wjg.v22.i43.9554]
Corresponding Author of This Article
Ralf Jakobs, MD, Medical Director, Medizinische Klinik C, Klinikum der Stadt Ludwigshafen, Bremserstraße 79, 67063 Ludwigshafen, Germany. jakobsr@klilu.de
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 21, 2016; 22(43): 9554-9561 Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9554
Self-expanding metal stents for the palliation of malignant gastric outlet obstruction in patients with peritoneal carcinomatosis
Christoph Rademacher, Matthias Bechtler, Steffen Schneider, Bettina Hartmann, Johannes Striegel, Ralf Jakobs
Christoph Rademacher, Matthias Bechtler, Bettina Hartmann, Johannes Striegel, Ralf Jakobs, Medizinische Klinik C, Klinikum der Stadt Ludwigshafen, 67063 Ludwigshafen, Germany
Steffen Schneider, Department of Statistics/Stiftung IHF, Institut für Herzinfarktforschung, Bremserstraße 79, 67063 Ludwigshafen, Germany
Author contributions: Rademacher C designed and performed the research and wrote the paper; Bechtler M supervised the research and provided clinical advice; Schneider S supervised and performed the statistical analysis; Hartmann B and Striegel J provided clinical advice; Jakobs R supervised the research and the report.
Institutional review board statement: The institutional review board (Ethik-Kommission, Landesärztekammer Rheinland-Pfalz, Germany) deemed it exempt from review.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: Informed consent for data sharing was not obtained but the presented data are anonymized and the risk of identification is low. No additional data are available. Questions regarding the technical procedure, statistical code and data can be addressed to the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ralf Jakobs, MD, Medical Director, Medizinische Klinik C, Klinikum der Stadt Ludwigshafen, Bremserstraße 79, 67063 Ludwigshafen, Germany. jakobsr@klilu.de
Telephone: +49-621-5034100 Fax: +49-621-5034114
Received: June 17, 2016 Peer-review started: June 17, 2016 First decision: August 29, 2016 Revised: September 8, 2016 Accepted: October 10, 2016 Article in press: October 10, 2016 Published online: November 21, 2016 Processing time: 154 Days and 12.5 Hours
Core Tip
Core tip: This is a retrospective study to evaluate the efficacy of self-expanding metal stents (SEMS) for the palliation of gastric outlet obstruction in patients with peritoneal carcinomatosis (PC). Between January 2008 and April 2014 we treated 62 patients with duodenal stents for palliation of malignant gastroduodenal obstruction. In most cases, obstruction was caused by pancreatic (47%) or gastric cancer (23%). Technical success was achieved in 96.8% and clinical success in 79% of all patients. Carcinomatosis was associated with a significantly lower clinical success rate (66.7% vs 88.6%, P = 0.036). Given the limited therapeutic options and a clinical success rate of at least 66.7% we believe that SEMS are a reasonable treatment option in patients with PC.
