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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2016; 22(43): 9534-9543
Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9534
Published online Nov 21, 2016. doi: 10.3748/wjg.v22.i43.9534
Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway
Song Hu, Li-Bin Jiang, Xiao-Jing Zou, Wei Yi, De-Ying Tian, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Hu S and Tian DY designed the research; Hu S, Jiang LB, Zou XJ and Yi W performed the research; Tian DY contributed new reagents/analytic tools; Hu S, Jiang LB and Tian DY analyzed the data; Hu S and Tian DY wrote the paper.
Supported by the National Natural Science Foundation of China , No. 81171559 .
Institutional review board statement: The study was reviewed and approved by the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Institutional Review Board.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: De-Ying Tian, PhD, Professor, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430030, Hubei Province, China. dytian@tjh.tjmu.edu.cn
Telephone: +86-130-18047239 Fax: +86-21-64085875
Received: August 24, 2016
Peer-review started: August 24, 2016
First decision: September 6, 2016
Revised: September 20, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: November 21, 2016
Processing time: 86 Days and 5.8 Hours
Peer-review started: August 24, 2016
First decision: September 6, 2016
Revised: September 20, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: November 21, 2016
Processing time: 86 Days and 5.8 Hours
Core Tip
Core tip: To date, few studies have investigated whether hepatitis B virus (HBV) hijacks the host hepatocyte’s demannosylation system to trim the mannose oligosaccharides found on its viral envelope, thereby evading DC-SIGN recognition. Our study showed that HBV could increase the expression of α-mannosidase I both in vitro and in vivo. Moreover, the HBV envelope protein increases the expression of α-mannosidase I via the PPARα pathway. Therefore, α-mannosidase I may be a novel drug target to inhibit the demannosylation of HBV, and prevent viral escape.