Zhang TY, Lin Y, Fan R, Hu SR, Cheng MM, Zhang MC, Hong LW, Zhou XL, Wang ZT, Zhong J. Potential model for differential diagnosis between Crohn's disease and primary intestinal lymphoma. World J Gastroenterol 2016; 22(42): 9411-9418 [PMID: 27895429 DOI: 10.3748/wjg.v22.i42.9411]
Corresponding Author of This Article
Jie Zhong, MD, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No 197 Ruijin Er Lu, Huangpu District, Shanghai 200025, China. jimmyzj64@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 14, 2016; 22(42): 9411-9418 Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9411
Potential model for differential diagnosis between Crohn's disease and primary intestinal lymphoma
Tian-Yu Zhang, Yun Lin, Rong Fan, Shu-Rong Hu, Meng-Meng Cheng, Mao-Chen Zhang, Li-Wen Hong, Xiao-Lin Zhou, Zheng-Ting Wang, Jie Zhong
Tian-Yu Zhang, Yun Lin, Rong Fan, Shu-Rong Hu, Meng-Meng Cheng, Mao-Chen Zhang, Li-Wen Hong, Xiao-Lin Zhou, Zheng-Ting Wang, Jie Zhong, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Author contributions: Zhong J conceived the study and served as a guarantor of integrity; Zhang TY and Lin Y contributed equally to this study, who designed the study and drafted the article; Fan R analyzed the data; Hu SR, Cheng MM, Zhang MC, Hong LW, Wang ZT and Zhou XL contributed to the data collection and interpretation.
Institutional review board statement: The Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine approved this study.
Informed consent statement: Informed consent was acquired from all the enrolled patients.
Conflict-of-interest statement: The authors declare that no conflicts of interest exist.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at jimmyzj64@hotmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jie Zhong, MD, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No 197 Ruijin Er Lu, Huangpu District, Shanghai 200025, China. jimmyzj64@hotmail.com
Telephone: +86-21-64370045 Fax: +86-21-64315951
Received: June 15, 2016 Peer-review started: June 16, 2016 First decision: July 12, 2016 Revised: July 18, 2016 Accepted: August 19, 2016 Article in press: August 19, 2016 Published online: November 14, 2016 Processing time: 149 Days and 17.8 Hours
Core Tip
Core tip: Crohn’s disease and primary intestinal lymphoma (PIL) have overlapping clinical manifestations. Misdiagnosis of PIL would lead to disastrous outcomes in patients. Consequently, the differential diagnosis between these two conditions has perplexed clinical practitioners for decades. In this article, we evaluated the usefulness of different parameters, including clinical manifestations, laboratory tests, endoscopic features, and computed tomographic enterographic characteristics for differentiating these two conditions and established an objective differentiation model that would yield a high diagnostic efficacy in order to avoid misdiagnosis of PIL. This is a first study which focuses on the differential diagnosis of these two diseases.
