Therapeutics Advances
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2016; 22(40): 8862-8868
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8862
Liver-targeted hydrodynamic gene therapy: Recent advances in the technique
Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Masafumi Oda, Takeshi Suda, Shuji Terai
Takeshi Yokoo, Kenya Kamimura, Hiroyuki Abe, Yuji Kobayashi, Tsutomu Kanefuji, Kohei Ogawa, Ryo Goto, Takeshi Suda, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata 951-8510, Japan
Masafumi Oda, Institute for Research Collaboration and Promotion, Niigata University, Niigata, Niigata 951-8510, Japan
Author contributions: Yokoo T, Kamimura K, Abe H, Kobayashi Y, Kanefuji T, Ogawa K, Goto R, Oda M, Suda T and Terai S all contributed to this paper.
Supported by in part Grant-in-Aid for Scientific Research from the Japanese Society for the Promotion of Sciences, No. 26860354 to Kamimura K, No. 16K19333 to Yokoo T, and No. 26293175 to Terai S.
Conflict-of-interest statement: The authors declare that they have no current financial arrangement or affiliation with any organization that may have a direct influence on their work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kenya Kamimura, MD, PhD, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp
Telephone: +81-25-2272207 Fax: +81-25-2270776
Received: July 4, 2016
Peer-review started: July 6, 2016
First decision: July 29, 2016
Revised: August 3, 2016
Accepted: August 23, 2016
Article in press: August 23, 2016
Published online: October 28, 2016
Processing time: 113 Days and 22 Hours
Core Tip

Core tip: Among a number of nonviral vector systems, hydrodynamic gene delivery has been used to study human diseases. The major advantage of the method is the simple and easy step to deliver naked DNA into living animal cells by physical force. The original method modification of injecting the DNA solution into a rodent tail vein has made it applicable in large animals. This method of delivering naked DNA can contribute to treat, not only liver disease but also other systemic diseases that can be cured by facilitating/altering gene expression through the liver.