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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2016; 22(4): 1582-1592
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1582
Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1582
Modulation of splanchnic circulation: Role in perioperative management of liver transplant patients
Ahmed Mukhtar, Department of Anesthesia and Critical Care, Cairo University, Cairo 11562, Egypt
Hany Dabbous, Department of Hepatology and Gastroenterology, Ain Shams University, Cairo 11566, Egypt
Author contributions: Mukhtar A contributed to the design of the review, as well as writing, revision, and final approval of the manuscript; Dabbous H contributed to writing, revision, and final approval of the manuscript.
Conflict-of-interest statement: The contributing authors have no conflicts of interest regarding the writing or publication of this minireview.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ahmed Mukhtar, MD, Professor, Department of Anesthesia and Critical Care, 1 Al-Saray Street, Al-Manial, Cairo University, Cairo 11562, Egypt. ahmed.mukhtar@kasralainy.edu.eg
Telephone: +2-11-14208444 Fax: +2-22-3641687
Received: April 29, 2015
Peer-review started: May 7, 2015
First decision: July 20, 2015
Revised: August 13, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: January 28, 2016
Processing time: 266 Days and 11.5 Hours
Peer-review started: May 7, 2015
First decision: July 20, 2015
Revised: August 13, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: January 28, 2016
Processing time: 266 Days and 11.5 Hours
Core Tip
Core tip: Perioperative modulation of splanchnic circulation may be beneficial when managing liver transplant recipients. The possible benefits include improved maintenance of central blood volume and renal perfusion, and minimization of high portal flow in small for size livers. Terlipressin is a promising drug candidate for use as a splanchnic modulator.