Letters To The Editor
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2016; 22(38): 8638-8640
Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8638
Role of concomitant therapy for Helicobacter pylori eradication: A technical note
Giuseppe Losurdo, Floriana Giorgio, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Alfredo Di Leo, Enzo Ierardi
Giuseppe Losurdo, Floriana Giorgio, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Alfredo Di Leo, Enzo Ierardi, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Author contributions: Losurdo G, Di Leo A and Ierardi E conceived the article; Losurdo G and Ierardi E wrote the article; Giorgio F, Iannone A, Principi M and Barone M collected the data; all Authors read and approved the final version of the manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Enzo Ierardi, Professor, Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. ierardi.enzo@gmail.com
Telephone: +39-80-5594034 Fax: +39-80-5593088
Received: July 11, 2016
Peer-review started: July 13, 2016
First decision: August 19, 2016
Revised: August 27, 2016
Accepted: September 12, 2016
Article in press: September 12, 2016
Published online: October 14, 2016
Processing time: 92 Days and 19.2 Hours
Core Tip

Core tip: Concomitant therapy is one of the most effective first line regimen for Helicobacter pylori eradication. The comparison with other regimens (sequential or triple) in a selected geographical region (China in this case) implies several issues. The low number of included studies, the lack of quality evaluation and the high heterogeneity may undermine the strength of a meta-analysis. Therefore, further studies are needed to prove which is the best first line eradication treatment in China, according to the geographical differences in antibiotic resistances.