Freeman HJ. Endocrine manifestations in celiac disease. World J Gastroenterol 2016; 22(38): 8472-8479 [PMID: 27784959 DOI: 10.3748/wjg.v22.i38.8472]
Corresponding Author of This Article
Hugh James Freeman, MD, CM, FRCPC, FACP, Department of Medicine (Gastroenterology), University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 14, 2016; 22(38): 8472-8479 Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8472
Endocrine manifestations in celiac disease
Hugh James Freeman
Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC V6T 1W5, Canada
Author contributions: Freeman HJ is responsible for all of this manuscript.
Conflict-of-interest statement: There is no conflict of interest for the author in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hugh James Freeman, MD, CM, FRCPC, FACP, Department of Medicine (Gastroenterology), University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada. hugfree@shaw.ca
Telephone: +1-604-8227216 Fax: +1-604-8227236
Received: June 29, 2016 Peer-review started: June 30, 2016 First decision: July 29, 2016 Revised: August 5, 2016 Accepted: August 23, 2016 Article in press: August 23, 2016 Published online: October 14, 2016 Processing time: 105 Days and 11.5 Hours
Core Tip
Core tip: Celiac disease (CD) is an immune-mediated intestinal disorder that may be closely linked to a number of extra-intestinal disorders, particularly endocrine diseases. These include thyroiditis, particularly in adults, and insulin-dependent diabetes mellitus, particularly in children and adolescents. Other endocrine disorders have also been recorded, including adrenal insufficiency and pituitary disease. Usually, only a single endocrine gland is involved in CD, but changes in multiple different glands has also been recorded. If an endocrine disorder is present, screening for CD, even without gastrointestinal symptoms, has been recommended. In established CD, regular follow-up and evaluation for the possible appearance of an occult endocrine disorder may also be appropriate.
