Siddiqui MRS, Bhoday J, Battersby NJ, Chand M, West NP, Abulafi AM, Tekkis PP, Brown G. Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales. World J Gastroenterol 2016; 22(37): 8414-8434 [PMID: 27729748 DOI: 10.3748/wjg.v22.i37.8414]
Corresponding Author of This Article
Dr. Gina Brown, Consultant Radiologist, Professor, Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, United Kingdom. gina.brown@rmh.nhs.uk
Research Domain of This Article
Oncology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2016; 22(37): 8414-8434 Published online Oct 7, 2016. doi: 10.3748/wjg.v22.i37.8414
Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales
Muhammed R S Siddiqui, Jemma Bhoday, Nicholas J Battersby, Manish Chand, Nicholas P West, Al-Mutaz Abulafi, Paris P Tekkis, Gina Brown
Jemma Bhoday, Manish Chand, Al-Mutaz Abulafi, Muhammed RS Siddiqui, Department of Colorectal Surgery, Croydon University Hospital, Croydon, London CR7 7YE, United Kingdom
Jemma Bhoday, Nicholas J Battersby, Gina Brown, Muhammed RS Siddiqui, Department of Radiology, Royal Marsden Hospital, Sutton SM2 5PT, United Kingdom
Nicholas P West, Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, St. James’s University Hospital, Leeds LS9 7TF, United Kingdom
Paris P Tekkis, Department of Surgery, Royal Marsden Hospital, Fulham Rd, London SM2 5PT, United Kingdom
Author contributions: Siddiqui MRS, Bhoday J and Battersby NJ performed the literature search; Siddiqui MRS and Brown G analysed the data; Chand M wrote and corrected the manuscript; Siddiqui MRS, West NP, Abulafi AM, Tekkis PP and Brown G wrote and corrected the manuscript and approved it for final submission.
Supported bythe Royal Marsden Hospital United Kingdom National Institute for Health Research Biomedical Research Centre (to Brown G); and the Yorkshire Cancer Research and Pathological Society of Great Britain and Ireland (to West NP).
Conflict-of-interest statement: None to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Gina Brown, Consultant Radiologist, Professor, Department of Radiology, Royal Marsden Hospital, Downs Rd, Sutton SM2 5PT, United Kingdom. gina.brown@rmh.nhs.uk
Telephone: +44-208-6613156 Fax: +44-208-6439414
Received: March 23, 2016 Peer-review started: March 23, 2016 First decision: May 12, 2016 Revised: July 4, 2016 Accepted: July 31, 2016 Article in press: August 1, 2016 Published online: October 7, 2016 Processing time: 191 Days and 16.5 Hours
Core Tip
Core tip: The degree of primary tumour regression following neo-adjuvant therapy identified on final histopathological specimens is a prognostic factor and response variation has allowed risk stratification, aiding in post-surgical treatment and follow-up decisions. To do this effectively, we need to have a common language for defining good and poor response. Definitions of response using histopathology scales are heterogenous with 19 different scales. There is one pre-operative magnetic resonance imaging (MRI) scale. Outcomes of recurrence and survival histopathology regression assessments should use Mandard 1, 2/Dworak 3, 4 for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mrTRG1-3 and mrTRG4-5, respectively.
