Meta-Analysis
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2016; 22(34): 7841-7850
Published online Sep 14, 2016. doi: 10.3748/wjg.v22.i34.7841
Double-layered covered stent for the treatment of malignant oesophageal obstructions: Systematic review and meta-analysis
Zeiad Hussain, Athanasios Diamantopoulos, Miltiadis Krokidis, Konstantinos Katsanos
Zeiad Hussain, Athanasios Diamantopoulos, Konstantinos Katsanos, Department of Interventional Radiology, Guy’s and St.Thomas’ Hospitals, NHS Foundation Trust, London SE1 7EH, United Kingdom
Miltiadis Krokidis, Department of Interventional Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom
Author contributions: Diamantopoulos A, Krokidis M and Katsanos K designed the systematic review; Hussain Z collected the data; Katsanos K analysed data; Hussain Z and Diamantopoulos A wrote the paper; and Katsanos K revised the paper.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Konstantinos Katsanos, MSc, MD, PhD, EBIR, Consultant Vascular and Interventional Radiology, Department of Interventional Radiology, Guy’s and St.Thomas’ Hospitals, NHS Foundation Trust, King’s Health Partners, London SE1 7EH, United Kingdom. konstantinos.katsanos@gstt.nhs.uk
Telephone: +44-207-1885550 Fax: +44-207-9288071
Received: March 28, 2016
Peer-review started: March 29, 2016
First decision: May 27, 2016
Revised: July 2, 2016
Accepted: August 1, 2016
Article in press: August 1, 2016
Published online: September 14, 2016
Processing time: 165 Days and 1 Hours
Core Tip

Core tip: The aim of this systematic review and meta-analysis is to investigate the efficacy of double-layered nitinol covered stent in the treatment of malignant oesophageal obstructions. The literature was searched following the PRISMA selection process as recommended by Cochrane. Weighted pooled outcomes were synthesized with a random effects model to account for clinical heterogeneity. This meta-analysis highlights the promising outcomes of the double-layered covered stent and demonstrates significant immediate relief of dysphagia with low rates of stent migration and tumour overgrowth. The unique design of this stent seems to combines the merits of both plain covered and uncovered metal esophageal stent designs.