Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2016; 22(32): 7365-7372
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7365
Prevalence of colorectal neoplasms in young, average risk individuals: A turning tide between East and West
Ari Leshno, Menachem Moshkowitz, Maayan David, Lior Galazan, Alfred I Neugut, Nadir Arber, Erwin Santo
Ari Leshno, Menachem Moshkowitz, Maayan David, Lior Galazan, Nadir Arber, Erwin Santo, Integrated Cancer Prevention Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Tel-Aviv 6997801, Israel
Menachem Moshkowitz, Nadir Arber, Erwin Santo, Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
Alfred I Neugut, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, United States
Alfred I Neugut, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, United States
Alfred I Neugut, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States
Author contributions: Leshno A and Moshkowitz M contributed equally to this work; Santo I and Arber N designed the study; David M and Galazan L participated in the acquisition and initial analysis of the data; Leshno A and Moshkowitz M analyzed and interpreted the data, and drafted the initial manuscript; Neugut AI, Arber N and Santo E revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Tel-Aviv Sourasky Medical Center Helsinki Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nadir Arber, MD, MHA, MSc, Professor, Head, Integrated Cancer Prevention Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, 6 Weizmann Street, Tel Aviv 6423906, Israel. nadira@tasmc.health.gov.il
Telephone: +972-3-6974968 Fax: +972-3-6974867
Received: March 15, 2016
Peer-review started: March 18, 2016
First decision: April 14, 2016
Revised: May 11, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: August 28, 2016
Processing time: 162 Days and 4.8 Hours
Core Tip

Core tip: This research focuses on evaluating detection rates of colorectal neoplasia among average risk individuals aged 40-59 years and comparing the detection rates between the fifth and sixth decades. In this prospective study of first screening colonoscopy from 1750 consecutive average risk subjects aged 40-59, we found that the prevalence of colorectal neoplasia is age and gender dependent. In addition we did an extensive search of the literature that revealed a markedly higher adenoma detection rate among Asians, and in particular Koreans compares to Western populations.