Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2016; 22(32): 7215-7225
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7215
Multisciplinary management of patients with liver metastasis from colorectal cancer
Kathleen De Greef, Christian Rolfo, Antonio Russo, Thiery Chapelle, Giuseppe Bronte, Francesco Passiglia, Andreia Coelho, Konstantinos Papadimitriou, Marc Peeters
Kathleen De Greef, Thiery Chapelle, Hepatobiliary, Transplant and endocrine surgery Department, Antwerp University Hospital, 2650 Edegem, Belgium
Christian Rolfo, Francesco Passiglia, Andreia Coelho, Phase I - Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp, Antwerp University Hospital, 2650 Edegem, Belgium
Antonio Russo, Giuseppe Bronte, Francesco Passiglia, Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90133 Palermo, Italy
Andreia Coelho, Oncology Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, 5000-508 Vila Real, Portugal
Konstantinos Papadimitriou, Marc Peeters, Oncology Department and Multidisciplinary Oncology Center Antwerp, Antwerp University Hospital, 2650 Edegem, Belgium
Author contributions: De Greef K and Rolfo C wrote the manuscript; De Greef K, Rolfo C, Russo A, Chapelle T, Bronte G, Passiglia F, Coelho A, Papadimitriou K and Peeters M contributed to the content of the manuscript, revision and final manuscript approval; De Greef K, Rolfo C and Peeters M conceived the idea and manuscript format; De Greef K and Rolfo C contributed equally to this work.
Conflict-of-interest statement: The authors declare no conflict of interest for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Christian Rolfo, MD, PhD, Professor, Head of Phase I, Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. christian.rolfo@uza.be
Telephone: +32-3-8213646
Received: March 7, 2016
Peer-review started: March 8, 2016
First decision: May 12, 2016
Revised: June 21, 2016
Accepted: August 1, 2016
Article in press: August 1, 2016
Published online: August 28, 2016
Processing time: 169 Days and 13.2 Hours
Core Tip

Core tip: Approximately 25% of colorectal cancer patients have liver metastases at the initial diagnosis and almost half develop liver metastases later. Although unresectable liver metastases can be converted into resectable disease with the help of combination chemotherapy with targeted therapy, patients should be accurately selected. Multidisciplinary teams including health professional with expertise in hepatobiliary disease is needed to decide the best way to manage these patients’ treatment.