Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2016; 22(31): 7157-7165
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7157
Prognostic significance of computed tomography-detected extramural vascular invasion in colon cancer
Xun Yao, Su-Xing Yang, Xing-He Song, Yan-Cheng Cui, Ying-Jiang Ye, Yi Wang
Xun Yao, Su-Xing Yang, Xing-He Song, Yi Wang, Department of Radiology, Peking University People’s Hospital, Beijing 100044, China
Yan-Cheng Cui, Ying-Jiang Ye, Department of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing 100044, China
Author contributions: Yao X collected and analyzed the data and drafted the manuscript; Yang SX and Song XH provided analytical oversight; Cui YC and Ye YJ offered material support; Wang Y designed and supervised the study and reviewed the final revision of the manuscript; all authors have read and approved the final version to be published.
Institutional review board statement: This retrospective study was approved by our local institutional review board, which waived the requirement for obtaining informed consent.
Conflict-of-interest statement: None of the authors have any conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi Wang, MD, PhD, Professor, Department of Radiology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. wangyi@pkuph.edu.cn
Telephone: +86-13331183901 Fax: +86-10-68318386
Received: April 12, 2016
Peer-review started: April 14, 2016
First decision: May 12, 2016
Revised: May 26, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: August 21, 2016
Processing time: 124 Days and 0.6 Hours
Core Tip

Core tip: The 4-point computed tomography extramural vascular invasion (ctEMVI) detection and grading system has been described and validated as a method for predicting disease-free survival (DFS) in colon cancer patients. In this study, we assess the difference in DFS between ctEMVI-positive and -negative colon cancer patients. ctEMVI status as well as pathological T and N status were independent adverse prognostic indicators for colon cancer patients. ctEMVI, in conjunction with the extent of extramural spread and lymph node burden, may become a novel and clinically significant imaging evaluation parameter when deciding whether patients with colon cancer should receive neoadjuvant treatment.