Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2016; 22(31): 7135-7145
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7135
Development of a human rotavirus induced diarrhea model in Chinese mini-pigs
Jin-Tao Li, Jing Wei, Hong-Xia Guo, Jiang-Bo Han, Nan Ye, Hai-Yang He, Tian-Tian Yu, Yu-Zhang Wu
Jin-Tao Li, Hong-Xia Guo, Jiang-Bo Han, Nan Ye, Tian-Tian Yu, Institute of Tropical Medicine, Third Military Medical University, Chongqing 400038, China
Jing Wei, Hai-Yang He, Yu-Zhang Wu, Institute of Immunology, PLA, Third Military Medical University, Chongqing 400038, China
Jing Wei, School of Life Science, Southwest University, Chongqing 400715, China
Author contributions: Li JT and Wei J contributed equally to this study and they designed the research and wrote the manuscript; Guo HX, Han JB, Ye N and Yu TT performed the research; He HY contributed new reagents and analytic tools; He HY analyzed the data; Wu YZ contributed the final approval of the article.
Supported by National Natural Science Foundation of China, No. 30400402; and No. 30571708.
Institutional review board statement: This study was reviewed and approved by the Third Military Medical University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving the care and use of animals were approved by The Institutional Animal Care and Use Committee of the Third Military Medical University.
Conflict-of-interest statement: All authors declare that they have no competing interests about the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Jin-Tao Li, PhD, Professor, Institute of Tropical Medicine, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, China.
Telephone: +86-23-68752329 Fax: +86-23-68752329
Received: March 16, 2016
Peer-review started: March 18, 2016
First decision: May 12, 2016
Revised: May 26, 2016
Accepted: June 13, 2016
Article in press: June 13, 2016
Published online: August 21, 2016
Core Tip

Core tip: Rotavirus (RV) is the leading cause of serious dehydrating diarrhea in infants and young children worldwide. Animal models for RV infection research have provided key insights into the RV infection, its pathogenesis and immunity, and have offered opportunities for design and evaluation of potential vaccines. Our study indicated that human RV (HRV) could effectively replicate in the intestinal villi of the ileum of Chinese mini-pigs and lead to histopathological alterations and diarrhea. This research offers a new animal model for studying the pathological changes and immunogenicity of HRV infection and a useful tool in the design and evaluation of RV vaccines.