MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling

doi:10.3748/wjg.v22.i29.6652

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 7, 2016; 22(29): 6652-6662
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6652

MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling

Jeongeun Hyun, Youngmi Jung

Jeongeun Hyun, Youngmi Jung, Department of Biological Sciences, College of Natural Science, Pusan National University, Pusan 46241, South Korea

Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.

Supported by the National Research Foundation of Korea funded by the Korean Government (MEST) to Jung Y; No. 2013R1A2A2A01068268.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Correspondence to: Youngmi Jung, PhD, Department of Biological Sciences, College of Natural Science, Pusan National University, Pusandaehak-ro 63beon-gil, Geumjeong-gu, Pusan 46241, South Korea. y.jung@pusan.ac.kr

Telephone: +82-51-5102262 Fax: +82-51-5812962

Received: April 1, 2016
Peer-review started: April 6, 2016
First decision: May 30, 2016
Revised: June 8, 2016
Accepted: June 29, 2016
Article in press: June 29, 2016
Published online: August 7, 2016
Processing time: 119 Days and 10.3 Hours

Core Tip

Core tip: MicroRNAs (miRNAs) influence various biological responses by controlling gene expression. Recent studies investigate the roles of miRNAs in liver fibrosis, due to their potential as biomarkers and therapeutic agents. Hedgehog (Hh) signaling contributes to hepatic fibrosis. Hence, regulation of Hh signaling is one of the therapeutic strategies against liver fibrogenesis. Therefore, we introduce miRNAs relevant to Hh signaling and discuss the interaction of miRNAs with Hh signaling, with a particular focus on the anti-fibrotic effect of Hh-regulating miRNAs in liver diseases. This review suggests that miRNAs-mediating Hh signaling are the novel diagnostic and therapeutic targets for treating liver disease.