Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2016; 22(29): 6629-6637
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6629
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6629
Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis
Zhen-Zhen Wu, Rui Zhou, Wang-Jun Liao, Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Li-Shan Chen, Medical Center for Overseas Patients, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Jian-Ping Bin, Yu-Lin Liao, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Wu ZZ and Chen LS contributed equally to this work; Wu ZZ, Chen LS and Zhou R performed the research and wrote the paper; Bin JP, Liao YL and Liao WJ critically revised the manuscript for important intellectual content.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wang-Jun Liao, MD, PhD, Department of Oncology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. nfyyliaowj@163.com
Telephone: +86-20-62787731 Fax: +86-20-62787731
Received: March 14, 2016
Peer-review started: March 16, 2016
First decision: March 31, 2016
Revised: April 17, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: August 7, 2016
Peer-review started: March 16, 2016
First decision: March 31, 2016
Revised: April 17, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: August 7, 2016
Core Tip
Core tip: Metastasis-associated in colon cancer-1 (MACC1) is an oncogene that is involved in multiple aspects of gastric cancer (GC). Although MACC1 was first identified as a promoter of the epithelial-mesenchymal transition in GC, as in colon cancer, it has subsequently been found to have functions in GC far beyond metastasis, including vasculogenic mimicry, lymphangiogenesis and metabolic reprogramming. These features of tumorigenesis and tumor progression involve both GC cells and the surrounding tumor microenvironment, indicating that the tumor-promoting functions of MACC1 may hinge on its ability to mediate the tumor microenvironment.