Resino E, San-Juan R, Aguado JM. Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation. World J Gastroenterol 2016; 22(26): 5950-5957 [PMID: 27468189 DOI: 10.3748/wjg.v22.i26.5950]
Corresponding Author of This Article
Elena Resino, PhD, Unit of Infectious Diseases, 12 de Octubre University Hospital, Carretera de Andalucía Km. 5.4, Madrid 28041, Spain. elenaresinofoz@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2016; 22(26): 5950-5957 Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.5950
Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation
Elena Resino, Rafael San-Juan, Jose Maria Aguado
Elena Resino, Rafael San-Juan, Jose Maria Aguado, Unit of Infectious Diseases, 12 de Octubre University Hospital, Madrid 28041, Spain
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: The authors of the present manuscript do not have other commercial or other association that might pose a conflict of interest (e.g., pharmaceutical stock ownership, consultancy, advisory board membership, or relevant patents). There was not any specific financial support for the research described in the present manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Elena Resino, PhD, Unit of Infectious Diseases, 12 de Octubre University Hospital, Carretera de Andalucía Km. 5.4, Madrid 28041, Spain. elenaresinofoz@gmail.com
Received: March 26, 2016 Peer-review started: March 27, 2016 First decision: April 14, 2016 Revised: May 6, 2016 Accepted: May 21, 2016 Article in press: May 23, 2016 Published online: July 14, 2016 Processing time: 102 Days and 1.5 Hours
Core Tip
Core tip: Liver transplantation has become the treatment of choice for many liver diseases. It is currently a routine procedure but is still associated with significant morbidity being infectious complications the leading cause of death. Selective intestinal decontamination (SID) is a prophylactic strategy that consists of the administration of non-absorbable or systemic antibiotics with scarce anaerobicidal activity in order to prevent or minimize the impact of endogenous infections by potentially pathogenic microorganisms. In this review, we focus on the knowledge regarding the current role of SID in liver transplant recipients. Multiple studies have evaluated the role of SID in the critically ill patient, and several observational studies, randomized clinical trials and a meta-analysis have focused in liver transplantation. Our aim is to consolidate the current literature to better outline the impact of SID in the prevention of infections in this setting.
