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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2016; 22(25): 5668-5677
Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5668
Genomic diversity of colorectal cancer: Changing landscape and emerging targets
Daniel H Ahn, Kristen K Ciombor, Sameh Mikhail, Tanios Bekaii-Saab
Daniel H Ahn, Tanios Bekaii-Saab, Division of Medical Oncology, Mayo Clinic, Phoenix, AZ 85054, United States
Kristen K Ciombor, Sameh Mikhail, Division of Medical Oncology, The Ohio State University Medical Center, Columbus, OH 43210, United States
Author contributions: All authors contributed to this paper with conception, drafting, revision and approval of the final version of the paper.
Conflict-of-interest statement: None of the authors have any potential conflicts of interest, and no financial support was used for the work of this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tanios Bekaii-Saab, MD, Division of Medical Oncology, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054, United States. bekaii-saab.tanios@mayo.edu
Telephone: +1-480-3424800 Fax: +1-480-3014675
Received: March 20, 2016
Peer-review started: March 22, 2016
First decision: May 12, 2016
Revised: May 20, 2016
Accepted: June 13, 2016
Article in press: June 13, 2016
Published online: July 7, 2016
Processing time: 106 Days and 7.2 Hours
Core Tip

Core tip: Tumor somatic variants have a prognostic role, in addition to treatment selection in patients with solid tumor malignancies, including colorectal cancer (CRC). The application of this knowledge in the development of novel, targeted therapies has resulted in improved patient outcomes in this disease. Our objective is to provide an overview of the genomic alterations present in CRC and its role in treatment implications, in addition to providing an overview of ongoing and future clinical trials.