Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2016; 22(22): 5193-5200
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5193
Chitooligosaccharides promote radiosensitivity in colon cancer line SW480
Fu-Shi Han, Shi-Jie Yang, Mou-Bin Lin, Ying-Qun Chen, Ping Yang, Jin-Ming Xu
Fu-Shi Han, Jin-Ming Xu, Department of Imaging, Tongji University Affiliated Yangpu Hospital, Shanghai 200090, China
Shi-Jie Yang, Tongji University School of Medicine, Shanghai 200092, China
Mou-Bin Lin, Department of General Surgery, Tongji University Affiliated Yangpu Hospital, Shanghai 200090, China
Ying-Qun Chen, Department of Traditional Chinese Medicine, Tongji University Affiliated Yangpu Hospital, Shanghai 200090, China
Ping Yang, Department of Gastroenterology, Tongji University Affiliated Yangpu Hospital, Shanghai 200090, China
Author contributions: Han FS, Yang SJ and Lin MB designed research; Han FS, Yang SJ, Lin MB, Chen YQ, Yang P and Xu JM performed research; Yang SJ, Lin MB and Chen YQ contributed new reagents/analytic tools; Han FS, Yang P and Xu JM analyzed data; and Han FS and Xu JM wrote the paper.
Supported by National Natural Science Foundation of China, No. 81272480.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jin-Ming Xu, Chief Physician, Department of Imaging, Tongji University Affiliated Yangpu Hospital, No. 450 Tengyue Road, Shanghai 200090, China. xu10611@hotmail.com
Telephone: +86-21-65690520
Received: January 24, 2016
Peer-review started: January 25, 2016
First decision: February 18, 2016
Revised: March 2, 2016
Accepted: March 18, 2016
Article in press: March 18, 2016
Published online: June 14, 2016
Processing time: 129 Days and 18.6 Hours
Core Tip

Core tip: In this study, the colorectal cancer cell line SW480 that is homologous with colon-rectum was used as the research tool. It was confirmed that chitooligosaccharides (COS) not only directly blocked SW480 cell proliferation, but also enhanced radiotherapy effects. Furthermore, COS induced a large amount of SW480 cell apoptosis, and induced a large number of cells to remain in the G2/M phase with radiation-sensitive killing effect. Thus, the sensitivity of SW480 cells to radiation was effectively enhanced 1.39 times. This is beneficial for the therapeutic effect.