Lim CH, Cho YS. Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management. World J Gastroenterol 2016; 22(2): 853-861 [PMID: 26811631 DOI: 10.3748/wjg.v22.i2.853]
Corresponding Author of This Article
Young-Seok Cho, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seoul 137-701, South Korea. yscho@catholic.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 14, 2016; 22(2): 853-861 Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.853
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management
Chul-Hyun Lim, Young-Seok Cho
Chul-Hyun Lim, Young-Seok Cho, Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Author contributions: Lim CH collected the materials and wrote the manuscript; Cho YS wrote the manuscript and supervised the publication of this review article.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Young-Seok Cho, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seoul 137-701, South Korea. yscho@catholic.ac.kr
Telephone: +82-2-22586021 Fax: +82-2-22582038
Received: June 20, 2015 Peer-review started: June 25, 2015 First decision: July 20, 2015 Revised: August 10, 2015 Accepted: October 23, 2015 Article in press: October 26, 2015 Published online: January 14, 2016 Processing time: 200 Days and 5.6 Hours
Core Tip
Core tip: Nonampullary duodenal adenomas are thought to progress to duodenal adenocarcinomas in a stepwise manner, with accumulation of genetic mutations, including those in APC, KRAS, and p53. Recently, using magnifying endoscopy with narrow band imaging, a novel diagnostic algorithm for real-time diagnosis of nonampullary superficial duodenal epithelial tumors was developed. Endoscopic mucosal resection may facilitate removal of large duodenal polyps. Although several studies have reported cases of successful endoscopic submucosal dissection for duodenal adenomas, the procedure is technically difficult to perform safely. Further studies are needed to develop newer endoscopic techniques for the diagnosis and treatment of nonampullary duodenal adenomas.
