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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2016; 22(2): 833-841
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.833
Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview
Vilma Oliveira Frick, Claudia Rubie, Ulrich Keilholz, Pirus Ghadjar
Vilma Oliveira Frick, Claudia Rubie, Department of General-, Visceral-, Vascular- and Pediatric Surgery, University of the Saarland, 66421 Homburg/Saar, Germany
Ulrich Keilholz, Charité Comprehensive Cancer Center, Charité Universitätsmedizin Berlin, Campus Charité Mitte, 10117 Berlin, Germany
Pirus Ghadjar, Department of Radiation Oncology, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany
Author contributions: Frick VO drafted the manuscript; Rubie C, Ghadjar P and Keilholz U revised the manuscript for important intellectual content.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Vilma Oliveira Frick, PhD, Department of General-, Visceral-, Vascular- and Pediatric Surgery, University of the Saarland, Building 57, 66421 Homburg/Saar, Germany. vilma.frick@uks.eu
Telephone: +49-6841-47867
Received: March 27, 2015
Peer-review started: March 30, 2015
First decision: June 25, 2015
Revised: July 17, 2015
Accepted: November 9, 2015
Article in press: November 9, 2015
Published online: January 14, 2016
Processing time: 284 Days and 21 Hours
Core Tip

Core tip: Here we review the current literature published with respect to the expression pattern of chemokine/chemokine receptor pair cysteine motif chemokine ligand 20 (CCL20)/CCR6 and their physiological interactions as well as the currently presumed role of the CCL20/CCR6 system in the onset and development of colorectal cancer (CRC) and its apparent role in the organ-selective metastatic spread of CRC cells to the liver. Disrupting the chemokine/chemokine receptor interaction of CCL20/CCR6 may therefore be a promising novel treatment strategy in CRC and metastasis.