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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2016; 22(16): 4160-4167
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4160
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4160
Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis
Mohamad Mokadem, Division of Gastroenterology and Hepatology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa, IA 52242, United States
Lama Noureddine, Division of Nephrology and Hypertension, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa, IA 52242, United States
Thomas Howard, Community Health Network, Indianapolis, IN 46219, United States
Lee McHenry, Stuart Sherman, Evan L Fogel, James L Watkins, Glen A Lehman, Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, IN 46202, United States
Author contributions: Mokadem M and Lehman GA designed the study; Mokadem M, Noureddine L, Howard T, McHenry L, Sherman S, Fogel EL, Watkins JL and Lehman GA executed the experiments; Mokadem M and Lehman GL drafted manuscript; Mokadem M, Noureddine L, Howard T, McHenry L, Sherman S, Fogel EL, Watkins JL and Lehman GA critically revised the manuscript.
Institutional review board statement: All experiments were in compliance with the ethics of the Institutional Review Board of Indiana University Medical Center.
Informed consent statement: Oral informed consent was obtained from all patients before performing the questionnaire.
Conflict-of-interest statement: All authors declare no conflicts of interest.
Data sharing statement: All collected data is present within the core of the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohamad Mokadem, MD, Division of Gastroenterology and Hepatology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 200 Hawkins Drive, 4570 JCP, Iowa, IA 52242, United States. mohamad-mokadem@uiowa.edu
Telephone: +1- 319-3846178 Fax: +1-319-3547981
Received: December 18, 2015
Peer-review started: December 20, 2015
First decision: December 30, 2015
Revised: January 20, 2016
Accepted: February 20, 2016
Article in press: February 22, 2016
Published online: April 28, 2016
Processing time: 123 Days and 1.3 Hours
Peer-review started: December 20, 2015
First decision: December 30, 2015
Revised: January 20, 2016
Accepted: February 20, 2016
Article in press: February 22, 2016
Published online: April 28, 2016
Processing time: 123 Days and 1.3 Hours
Core Tip
Core tip: Total pancreatectomy (TP) is the last resort offered to chronic pancreatitis (CP) patients with intractable pain when other interventions have failed. We wanted to compare pain control and rate of insulin-dependent diabetes in CP patients after TP and autologous islet cell transplantation (ICT) or intrathecal narcotic pump infusion, which is a relatively new and less invasive technique used for chronic analgesia in multiple other clinical settings. We found that pain control was similar between the two interventions after a median follow-up of 3 years yet the rate of insulin-dependent diabetes was still high in the surgical resection group despite the ICT.