Han FH, Zhou SN, Li HM, He YL, Zhan WH. Vascularizing lymph node dissection for advanced gastric cancer: A single-institution experience. World J Gastroenterol 2016; 22(14): 3813-3820 [PMID: 27076766 DOI: 10.3748/wjg.v22.i14.3813]
Corresponding Author of This Article
Wen-Hua Zhan, PhD, Department of Gastrointestinal-Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Erlu, Guangzhou 510000, Guangdong Province, China. wh_zhan@126.com
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fang-Hai Han, Sheng-Ning Zhou, Hong-Ming Li, Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China
Yu-Long He, Wen-Hua Zhan, Department of Gastrointestinal-Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China
Author contributions: Han FH and Zhou SN contributed equally to this work; Han FH and Zhou SN designed the research; Zhan WH, He YL and Han FH performed the research; Li HM contributed new reagents or analytic tools; Zhou SN analyzed the data; Han FH and Zhou SN wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Sun Yat-sen Memorial Hospital.
Informed consent statement: All study participants, or their legal guardian, provided verbal informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wen-Hua Zhan, PhD, Department of Gastrointestinal-Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan Erlu, Guangzhou 510000, Guangdong Province, China. wh_zhan@126.com
Telephone: +86-20-28823388
Received: October 11, 2015 Peer-review started: October 12, 2015 First decision: December 11, 2015 Revised: December 17, 2015 Accepted: January 17, 2016 Article in press: January 18, 2016 Published online: April 14, 2016 Processing time: 170 Days and 14.9 Hours
Core Tip
Core tip: This study investigates the short- and long-term outcomes of vascularizing lymph node dissection (VLND) and non-vascularizing lymph node dissection (NVLND) from a single institution. The overall 5-year survival rate was 64% in the VLND group and 59% in the NVLND group (P = 0.047). We draw a conclusion that VLND with D2 lymphadenectomy has overall survival benefit for patients with advanced gastric cancer without significant operative complications and mortality if performed by a well-trained and experienced surgical team. If undifferentiated adenocarcinoma is confirmed by endoscopic biopsy preoperatively or macroscopically enlarged regional lymph nodes are found intraoperatively in advanced gastric cancer, VLND with D2 lymphadenectomy may be a considerable alternative.
