Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2016; 22(13): 3516-3530
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3516
Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy
Oscar Murcia, Miriam Juárez, Eva Hernández-Illán, Cecilia Egoavil, Mar Giner-Calabuig, María Rodríguez-Soler, Rodrigo Jover
Oscar Murcia, Miriam Juárez, Eva Hernández-Illán, Cecilia Egoavil, Mar Giner-Calabuig, María Rodríguez-Soler, Rodrigo Jover, Unidad de Gastroenterología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria Isabial, 03010 Alicante, Spain
Author contributions: Murcia O wrote the first draft of the manuscript; Juárez M, Hernández-Illán E, Egoavil C and Giner-Calabuig M critically reviewed and corrected the manuscript; Rodríguez-Soler M and Jover R set the last version of this manuscript.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Rodrigo Jover, Unidad de Gastroenterología, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria Isabial, 12 Pintor Baeza, 03010 Alicante, Spain. rodrigojover@gmail.com
Telephone: +34-965-933468 Fax: +34-965-933468
Received: November 11, 2015
Peer-review started: November 12, 2015
First decision: November 27, 2015
Revised: December 4, 2015
Accepted: January 30, 2016
Article in press: January 30, 2016
Published online: April 7, 2016
Processing time: 137 Days and 15.8 Hours
Core Tip

Core tip: Recently, the implication among colorectal cancers with methylator phenotype has burst into the gastroenterology literature. In this review, we analyze the correlation between serrated cancers, the methylator phenotype and other genetic features in order to assess their prognosis and response to adjuvant chemotherapy.