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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2016; 22(12): 3341-3354
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3341
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3341
Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo
Rui Peng, Guang-Xi Zhao, Jing Li, Yu Zhang, Xi-Zhong Shen, Ji-Yao Wang, Jian-Yong Sun, Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Author contributions: Peng R and Zhang Y performed the majority of experiments; Zhao GX and Li J provided vital reagents and analytical tools and were also involved in editing the manuscript; Shen XZ, Wang JY and Sun JY co-ordinated and provided the collection of all the human material in addition to providing financial support for this work; Peng R and Sun JY designed the study and wrote the manuscript.
Supported by Science and Technology Commission of Shanghai, No. 13ZR1406700 and No. 13DZ1930908.
Institutional review board statement: The study was reviewed and approved by the Zhongshan Hospital of Fudan University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Zhongshan Hospital (IACUC protocol number: SCXK2013-0016).
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at sun_jianyong1986@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Yong Sun, PhD, Department of Gastroenterology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China. sun_jianyong1986@163.com
Telephone: +86-10-64041990 Fax: +86-10-64041990
Received: November 15, 2015
Peer-review started: November 16, 2015
First decision: December 11, 2015
Revised: January 8, 2016
Accepted: January 30, 2016
Article in press: January 30, 2016
Published online: March 28, 2016
Processing time: 128 Days and 20.3 Hours
Peer-review started: November 16, 2015
First decision: December 11, 2015
Revised: January 8, 2016
Accepted: January 30, 2016
Article in press: January 30, 2016
Published online: March 28, 2016
Processing time: 128 Days and 20.3 Hours
Core Tip
Core tip: This is the first study intending to evaluate the antioncogenic effects of Auphen and dibutyryl cAMP (dbcAMP) in vivo and investigate whether their underlying mechanism involves regulating aquaporin 3 (AQP3) and AQP9 expression. An in-depth description of AQP3 and AQP9 regulation by Auphen and dbcAMP will provide a better understanding of the mechanisms of hepatocarcinogenesis, which could be used in the development of novel therapeutic drugs. This work further confirms the significance of AQP-driven hepatocarcinogenesis, emphasizing the importance of both basic and clinical knowledge of the roles of aquaporins in hepatocellular carcinoma.