Caligiuri P, Cerruti R, Icardi G, Bruzzone B. Overview of hepatitis B virus mutations and their implications in the management of infection. World J Gastroenterol 2016; 22(1): 145-154 [PMID: 26755866 DOI: 10.3748/wjg.v22.i1.145]
Corresponding Author of This Article
Dr. Patrizia Caligiuri, Department of Health Sciences, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy. patrizia.caligiuri@libero.it
Research Domain of This Article
Virology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Patrizia Caligiuri, Giancarlo Icardi, Department of Health Sciences, University of Genoa, 16132 Genoa, Italy
Rita Cerruti, Giancarlo Icardi, Bianca Bruzzone, Hygiene Unit, I.R.C.C.S. A.O.U. San Martino-IST, 16132 Genoa, Italy
Author contributions: Caligiuri P, Cerruti R, Icardi G and Bruzzone B analyzed the literature and wrote this review.
Conflict-of-interest statement: The authors have no conflict of interest regarding this review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Patrizia Caligiuri, Department of Health Sciences, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy. patrizia.caligiuri@libero.it
Telephone: +39-10-5600591 Fax: +39-10-5600912
Received: May 29, 2015 Peer-review started: June 3, 2015 First decision: July 14, 2015 Revised: August 19, 2015 Accepted: December 1, 2015 Article in press: December 1, 2015 Published online: January 7, 2016 Processing time: 216 Days and 7.6 Hours
Core Tip
Core tip: Hepatitis B virus (HBV) is a global health problem, with almost 2 billion infected persons, many of whom deemed to develop chronic carrier state and eventually die from cirrhosis or liver cancer. Unlike in other DNA viruses, its high mutation rate and replicative capability arise considerable genetic variability, recently analyzed by molecular biology tools. HBV mutations occur in all four overlapping open reading frames encoding viral polymerase, surface antigen, core and X protein. Understanding the correlation between mutations and liver disease progression is crucial for an effective clinical management in HBV patients with resistance to antiviral drugs, hepatitis B surface antigen escape mutant, “occult” hepatitis and hepatocellular carcinoma.
