Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2830-2835
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2830
Postsurgical radiation therapy for gastric carcinosarcoma with c-kit expression: A case report
Takeshi Gohongi, Hiroyuki Iida, Naoto Gunji, Kazuo Orii, Takesaburo Ogata
Takeshi Gohongi, Hiroyuki Iida, Naoto Gunji, Kazuo Orii, Takesaburo Ogata, Department of Surgery and Pathology, Tsukuba-Gakuen Hospital, Ibaraki 305-0857, Japan
Author contributions: Gohongi T and Ogata T designed the report; Ogata T performed the pathologic studies; Gohongi T, Iida H, Gunji N and Orii K performed the surgery and treatment thereafter; and Gohongi T wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Takesaburo Ogata, MD, PhD, Department of Surgery and Pathology, Tsukuba-Gakuen Hospital, 2573-1 Kamiyokoba, Tsukuba, Ibaraki 305-0857, Japan. gohon@gakuen-hospital.or.jp
Telephone: +81-29-8361355 Fax: +81-29-8361590
Received: August 30, 2014
Peer-review started: August 31, 2014
First decision: September 27, 2014
Revised: November 13, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 7, 2015
Processing time: 191 Days and 4.8 Hours
Core Tip

Core tip: Gastric carcinosarcoma is a rare tumor for which there is no established definitive treatment. We present the first report of gastric carcinosarcoma with c-kit expression treated with neoadjuvant chemotherapy, surgical resection and radiation therapy. Radiation therapy to the metastatic tumors dramatically reduced their size and the patient survived 22 mo after surgery with a good quality of life. Although the relation between c-kit expression and radiation susceptibility remains unknown, this report provides new insight into the treatment of gastric carcinosarcoma for improved prognosis.