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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2820-2825
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2820
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2820
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome
Meghan R Flanagan, Arjun Jayaraj, Venu G Pillarisetty, Department of Surgery, University of Washington Medical Center, University of Washington, Seattle, WA 98195, United States
Wei Xiong, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Vancouver, BC V6Z 1Y6, Canada
Matthew M Yeh, Department of Pathology, University of Washington Medical Center, University of Washington, Seattle, WA 98195, United States
Wendy H Raskind, Departments of Medicine/Medical Genetics and Pyschiatry and Behavioral Sciences, University of Washington Medical Center, University of Washington, Seattle, WA 98195, United States
Author contributions: Xiong W and Yeh MM carried out molecular genetic studies; Flanagan MR, Jayaraj A and Pillarisetty VG conceived of the study and drafted the manuscript; Raskind WH was involved in literature review and critical revision of the manuscript; all authors read and approved the final manuscript.
Supported by University of Washington Department of Surgery, Seattle, WA.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Venu G Pillarisetty, MD, Assistant Professor, Department of Surgery, University of Washington Medical Center, University of Washington, 1959 NE Pacific St. Box 356410, Seattle, WA 98195, United States. vgp@uw.edu
Telephone: +1-206-6164924 Fax: +1-206-6168136
Received: August 5, 2014
Peer-review started: August 6, 2014
First decision: September 15, 2014
Revised: October 18, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 7, 2015
Processing time: 215 Days and 17.5 Hours
Peer-review started: August 6, 2014
First decision: September 15, 2014
Revised: October 18, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 7, 2015
Processing time: 215 Days and 17.5 Hours
Core Tip
Core tip: Intraductal papillary mucinous neoplasms (IPMN) are now recognized as important precursor lesions to pancreatic cancer. Although there have been reports linking pancreatic cancer and familial cancer syndromes, only one previous case report has described IPMN in a patient with Lynch syndrome. Our case is a main duct IPMN that contained only low-grade dysplasia and no microsatellite instability despite the presence of a germline MSH2 mutation. Mismatch repair (MMR) gene mutations may be involved in the neoplastic changes that drive the development of IPMN; however, changes in MMR function may not be detectable in the setting of low-grade neoplasia.