Yang JJ, Hu ZG, Shi WX, Deng T, He SQ, Yuan SG. Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis. World J Gastroenterol 2015; 21(9): 2807-2815 [PMID: 25759553 DOI: 10.3748/wjg.v21.i9.2807]
Corresponding Author of This Article
Song-Qing He, MD, Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China. dr_hesongqing@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jian-Jun Yang, Zhi-Gao Hu, Song-Qing He, Sheng-Guang Yuan, Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Wu-Xiang Shi, Te Deng, Department of Epidemiology and Biostatistics, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi Zhuang Autonomous Region, China
Song-Qing He, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Author contributions: Yang JJ and Hu ZG performed the research and wrote the paper; He SQ and Yuan SG designed the study; Shi WX and Deng T analyzed the data; and Yang JJ and Hu ZG contributed equally to this work.
Supported by Natural Science Foundation of Guangxi Province, No. 2013GXNSFAA019196 (in part); and the Science and Technology Planning Project of Guilin City, No. 20100128-5.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Song-Qing He, MD, Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China. dr_hesongqing@163.com
Telephone: +86-773-2809503 Fax: +86-773-2862270
Received: July 1, 2014 Peer-review started: July 2, 2014 First decision: July 21, 2014 Revised: August 8, 2014 Accepted: October 15, 2014 Article in press: October 15, 2014 Published online: March 7, 2015 Processing time: 251 Days and 3.6 Hours
Core Tip
Core tip: We performed a meta-analysis to evaluate the relationship between the peripheral blood neutrophil to lymphocyte ratio (NLR) and outcome of patients with pancreatic cancer. The results showed that high NLR was a poor prognostic marker and high NLR was associated with poor overall survival in patients with mixed treatment, chemotherapy, or surgical resection. Furthermore, high NLR was significantly correlated with tumor metastasis, poor tumor differentiation, poor performance status, high carbohydrate antigen 199, high C-reactive protein, and low albumin. This is the first comprehensive and detailed analysis for evaluating the prognostic value of the NLR and its association with the clinicopathological features for pancreatic cancer patients. NLR might be a novel marker of the survival evaluation for pancreatic cancer patients.
