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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2700-2710
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2700
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2700
Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine
Reiko Kumagai, Kenichi Kohashi, Shunsuke Takahashi, Hidetaka Yamamoto, Minako Hirahashi, Yoshinao Oda, Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Kenichi Taguchi, Department of Pathology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan
Kenichi Nishiyama, Division of Pathology, Japanese Red Cross Fukuoka Hospital, Fukuoka 815-8555, Japan
Author contributions: Kumagai R and Kohashi K performed the experiments, and the statistical analysis and drafted the manuscript; Kumagai R and Takahashi S carried out the experiments and analyzed the data; Kumagai R and Nishiyama K collected the data; Yamamoto H gave technical support and conceptual advice; Hirahashi M, Taguchi K and Oda Y participated in the design of the study and helped to draft the manuscript.
Ethics approval: The study was reviewed and approved by the Institutional Review Board of Kyushu University (IRB#25-191).
Informed consent: Informed consent was not obtained, but this study is not an interventional study and we completely anonymized or omitted all the information that might disclose the identity of the subjects.
Conflict-of-interest: The authors declare that there are no conflicts of interest to disclose.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yoshinao Oda, Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. oda@surgpath.med.kyushu-u.ac.jp
Telephone: +81-92-6426061 Fax: +81-92-6425968
Received: October 11, 2014
Peer-review started: October 13, 2014
First decision: October 29, 2014
Revised: November 13, 2014
Accepted: December 20, 2014
Article in press: December 22, 2014
Published online: March 7, 2015
Processing time: 148 Days and 19.1 Hours
Peer-review started: October 13, 2014
First decision: October 29, 2014
Revised: November 13, 2014
Accepted: December 20, 2014
Article in press: December 22, 2014
Published online: March 7, 2015
Processing time: 148 Days and 19.1 Hours
Core Tip
Core tip: This study analyzed the immunohistochemical expression of mucin core proteins (MUC5AC, MUC6 and MUC2), CD10 and mismatch-repair proteins (MLH1, MSH2), microsatellite instability (MSI), and the mutational status of KRAS and BRAF in 47 primary small intestinal adenocarcinoma. We suggest that the mucin phenotype and CD10 expression of small intestinal adenocarcinoma correlates with biological behavior, genetic alteration, and MSI status. Notably, the preservation of CD10 expression may be correlated with favorable biological behavior. The SIA with co-expression of MUC5AC and MUC2 was correlated with MSI-H status and mucinous adenocarcinoma, similar to colorectal carcinoma.