Wang W, Yang SF, Ren LH, Zhang XX, Yu SL. Effect of bifidobacterium on defensin-5 expression in intestinal injury of preweaning rats. World J Gastroenterol 2015; 21(9): 2638-2644 [PMID: 25759531 DOI: 10.3748/wjg.v21.i9.2638]
Corresponding Author of This Article
Wei Wang, MD, Department of Pediatrics, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province, China. wendywang_1972@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Wei Wang, Shu-Fen Yang, Li-Hong Ren, Xiu-Xiu Zhang, Shui-Lian Yu, Department of Pediatrics, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Author contributions: Wang W designed and performed the research, analyzed the data and wrote the paper; Yang SF designed and performed the research; Ren LH designed the research and analyzed the data; Zhang XX and Yu SL contributed new reagents or analytic tools.
Supported by Foundation of Education Department of Heilongjiang Province, No. 11521124.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Wei Wang, MD, Department of Pediatrics, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province, China. wendywang_1972@126.com
Telephone: +86-451-86605665 Fax: +86-451-86605665
Received: September 21, 2014 Peer-review started: September 21, 2014 First decision: October 14, 2014 Revised: October 29, 2014 Accepted: December 5, 2014 Article in press: December 8, 2014 Published online: March 7, 2015 Processing time: 169 Days and 7.2 Hours
Core Tip
Core tip: This study investigated the serum and ileal contents of myeloperoxidase (MPO) and the expression of ileal Defensin-5 mRNA in the preweaning rats with lipopolysaccharide (LPS)-induced intestinal injury. Serum and ileal MPO contents in the model group (group E) were significantly higher than those in the control group (group C) (P < 0.05), which peaked at 12 h and 6 h, respectively. MPO contents in the treatment group (group T) were significantly lower than those in group E (P < 0.05). The expression of defensin-5 mRNA in group E was significantly up-regulated, peaked at 2 h, and then decreased gradually. The expression of defensin-5 mRNA in group T was significantly lower than that in group E (P < 0.05). Serum and ileal MPO contents and ileal expression of defensin-5 mRNA increased in preweaning rats with LPS-induced intestinal injury. Bifidobacterium protects the gut by inhibiting MPO activity, not by increasing defensin-5 secretion.
