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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2629-2637
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2629
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2629
Combined detection of plasma GATA5 and SFRP2 methylation is a valid noninvasive biomarker for colorectal cancer and adenomas
Xie Zhang, Yu-Fei Song, Hong-Na Lu, Xue-Song Zhang, Shi-Liang Huang, Bei-Lei Sun, Department of Gastroenterology, Ningbo Medical Treatment Center Li Huili Hospital, Ningbo 315040, Zhejiang Province, China
Dan-Ping Wang, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang Province, China
Zhi-Gang Huang, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou 310014, Zhejiang Province, China
Author contributions: Zhang X and Song YF contributed equally to this work; Zhang X and Huang ZG designed the research; Zhang X, Song YF, Lu HN, Wang DP, Zhang XS, Huang SL and Sun BL performed the research; Zhang X, Song YF and Huang ZG analyzed the data; Zhang X, Song YF and Huang ZG wrote the paper.
Supported by Social Development Foundation of Ningbo, No. 2011C50022; Natural Science Foundation of Ningbo, No. 2012A610212; and the Scientific Innovation Team Project of Ningbo, No. 2013B82010.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Gang Huang, MD, Associate Professor, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, 158# Shangtang Road, Xiacheng District, Hangzhou 310014, Zhejiang Province, China. huangzg@foxmail.com
Telephone: +86-574-87018768 Fax: +86-574-87018768
Received: September 10, 2014
Peer-review started: September 11, 2014
First decision: October 14, 2014
Revised: October 31, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 7, 2015
Processing time: 180 Days and 4.3 Hours
Peer-review started: September 11, 2014
First decision: October 14, 2014
Revised: October 31, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 7, 2015
Processing time: 180 Days and 4.3 Hours
Core Tip
Core tip: Hypermethylated GATA5 was identified as a novel plasma gene in colorectal cancer (CRC) and adenomas, and it showed high potential as a biomarker in plasma-based DNA testing. Furthermore, this study suggests that a combination of GATA5 and SFRP2 methylation could be used as a promising marker for the detection, diagnosis, and prognosis of CRC and adenomas.