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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2015; 21(8): 2522-2533
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2522
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2522
Meta-analysis: Is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Hui-Lie Zheng, School Public Health, Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Lv ZF and Wang FC contributed equally to this work; Lv ZF, Wang FC performed the experiments, analyzed the data, and wrote the manuscript; Zheng HL analyzed the data; Wang B performed the experiments, analyzed the data and wrote the manuscript; Xie Y and Zhou XJ conceived, designed, and performed the experiments, and edited manuscript as corresponding author; Lv NH performed the experiments.
Supported by Grants from National Science and Technology Major Projects for “Major New Drugs Innovation and Development” of China, No. 2011ZX09302-007-03.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yong Xie, MD, PhD, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, No. 17 Yongwaizhengjie, Nanchang 330006, Jiangxi Province, China. xieyong_med@163.com
Telephone: +86-791-88692507 Fax: +86-791-88623153
Received: June 18, 2014
Peer-review started: June 19, 2014
First decision: July 9, 2014
Revised: July 20, 2014
Accepted: August 28, 2014
Article in press: August 28, 2014
Published online: February 28, 2015
Peer-review started: June 19, 2014
First decision: July 9, 2014
Revised: July 20, 2014
Accepted: August 28, 2014
Article in press: August 28, 2014
Published online: February 28, 2015
Core Tip
Core tip: The combination of amoxicillin and tetracycline is an attractive alternative because of its low cost, low resistance rate, and safety. We conducted this systematic review and meta-analysis of clinical trials to compare the efficacy of the combination of amoxicillin and tetracycline with other therapies for Helicobacter pylori (H. pylori) infection. Available data suggest that 10- or 14-d quadruple regimens with amoxicillin and tetracycline can achieve acceptable eradication rates and may be suitable for the treatment of H. pylori infection.