Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2015; 21(8): 2483-2489
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2483
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2483
Effect of pronase as mucolytic agent on imaging quality of magnifying endoscopy
Gwang Ha Kim, Department of Internal Medicine, Pusan National University School of Medicine, Pusan 602-739, South Korea
Yu Kyung Cho, Department of Internal Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Jae Myung Cha, Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Seoul 134-727, South Korea
Sun-Young Lee, Department of Internal Medicine, Konkuk University Medical Center, Seoul 134-727, South Korea
Il-Kwun Chung, Department of Internal Medicine, Soonchunhyang University, Cheonan 330-090, South Korea
Author contributions: All the authors contributed to this manuscript.
Supported by Research grant from Pharmbio Korea, Co. Ltd., Seoul, South Korea.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu Kyung Cho, Associate Professor, Department of Internal Medicine, The Catholic University of Korea, 505 Banpodong, Seochogu, Seoul St. Mary’s Hospital, Seoul 137-701, South Korea. ykcho@catholic.ac.kr
Telephone: + 82-2-22586024 Fax: + 82-2-22582055
Received: July 30, 2014
Peer-review started: July 31, 2014
First decision: August 15, 2014
Revised: September 14, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: February 28, 2015
Processing time: 212 Days and 23.9 Hours
Peer-review started: July 31, 2014
First decision: August 15, 2014
Revised: September 14, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: February 28, 2015
Processing time: 212 Days and 23.9 Hours
Core Tip
Core tip: Magnifying endoscopy is typically used to detect and diagnose small upper gastrointestinal tract cancers. Premedication with the proteolytic enzyme pronase improved the quality of magnified endoscopic images and required fewer water flushes to achieve satisfactory endoscopic viewing. It is unclear if the use of pronase will influence cancer detection rates or patient outcomes. However, pronase can be considered as a method of maximizing the diagnostic efficacy of high-resolution endoscopic techniques.