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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2015; 21(8): 2336-2342
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2336
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2336
Biological effects of low-dose-rate irradiation of pancreatic carcinoma cells in vitro using 125I seeds
Zhong-Min Wang, Jian Lu, Li-Yun Zhang, Zhi-Jin Chen, Department of Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
Zhong-Min Wang, Institution of Molecular Imaging, Southeast University, Nanjing 210009, China; Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Jian Lu, Li-Yun Zhang, Soochow University School of Medicine, Soochow 215123, Jiangsu Province, China
Xiao-Zhu Lin, Ke-Min Chen, Fu-Hua Yan, Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Fen-Ju Liu, Department of Radiobiology, School of Radiological Medicine and Protection, Soochow University, Soochow 215123, Jiangsu Province, China
Gao-Jun Teng, Institution of Molecular Imaging, Southeast University, Nanjing 210009, Jiangsu Province, China
Ai-Wu Mao, Department of Interventional Radiology, Shanghai St. Luke’s Hospital, Shanghai 200050, China
Author contributions: Wang ZM and Lu J contributed equally to this work. Wang ZM, Lu J, Lin XZ, Chen KM, Liu FJ, Teng GJ, and Mao AW designed the research; Lu J, Lin XZ, Zhang LY, Chen ZJ, and Liu FJ performed the research; Wang ZM, Lu J, Lin XZ, Zhang LY, Chen ZJ, and Liu FJ analyzed the data; and Lu J, Lin XZ, and Liyun Zhang wrote the paper. All authors read and approved the final manuscript.
Supported by Natural Science Foundation of China, No. 81271682 (partly); and grants from Science and Technology Commission of Shanghai Municipality, No. 11JC1407400 (partly); the project of Luwan District Science and Technology Commission of Shanghai, No. LKW1104 (partly); the project of Medical Key Specialty of Shanghai Municipality, No. ZK2012A20 (partly).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ai-Wu Mao, MD, Professor, Department of Interventional Radiology, Shanghai St. Luke’s Hospital, No. 786 Yu Yuan Road, Shanghai 200050, China. james0722@163.com
Telephone: +86-21-62524259 Fax: +86-21-62113884
Received: August 17, 2014
Peer-review started: August 17, 2014
First decision: September 15, 2014
Revised: September 30, 2014
Accepted: December 8, 2014
Article in press: December 8, 2014
Published online: February 28, 2015
Processing time: 195 Days and 3.1 Hours
Peer-review started: August 17, 2014
First decision: September 15, 2014
Revised: September 30, 2014
Accepted: December 8, 2014
Article in press: December 8, 2014
Published online: February 28, 2015
Processing time: 195 Days and 3.1 Hours
Core Tip
Core tip: We compared the radiobiological effects observed in SW1990 and PANC-1 pancreatic cancer cell lines after irradiation with 125I seeds through a clonogenic cell survival assay and 3H-TdR incorporation experiment. Continuous low-dose-rate irradiation with 125I seeds was found to induce apoptosis and G2/M cell cycle arrest.