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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1972-1981
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1972
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1972
Chronic hepatitis C genotype 1 treatment roadmap for resource constrained settings
Seng Gee Lim, Department of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Author contributions: Lim SG contributed to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seng Gee Lim, MBBS, MD, FRCP, FRACP, FAMS, Director of Hepatology, Department of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119228, Singapore. mdclimsg@nus.edu.sg
Telephone: +65-67724369 Fax: +65-67724361
Received: June 18, 2014
Peer-review started: June 19, 2014
First decision: July 9, 2014
Revised: July 21, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: February 14, 2015
Peer-review started: June 19, 2014
First decision: July 9, 2014
Revised: July 21, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: February 14, 2015
Core Tip
Core tip: Lex management of hepatitis C virus (HCV) genotype 1 using a simplified road map and "80-80" rule can help physicians manage their patients better. This roadmap distills the essential findings from using pegylated interferon and ribavirin as well as boceprevir using treatment week 4 and 8 virological responses based on whether HCVRNA is detectable or not.