Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1956-1971
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1956
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1956
Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis
A Boudewijn de Vries, Marcel Janse, Hans Blokzijl, Rinse K Weersma, Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
Author contributions: de Vries AB and Janse M performed the research, analyzed the data, and wrote the manuscript; Blokzijl H and Weersma RK were responsible for the study concept and design and were involved in editing and revision of the manuscript; all authors gave their final approval of the published version.
Supported by Partners Seeking a Cure and a VIDI grant from the Netherlands Organization for Scientific Research, No. 016.136.308 (to Weersma RK).
Conflict-of-interest: All authors have no conflict of interest related to the manuscript.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rinse K Weersma, MD, PhD, Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, PO Box 30001, Hanzeplein 1, 9700 RB Groningen, The Netherlands. r.k.weersma@umcg.nl
Telephone: +31-50-3610426 Fax: +31-50-3619306
Received: June 11, 2014
Peer-review started: June 12, 2014
First decision: August 6, 2014
Revised: October 31, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: February 14, 2015
Peer-review started: June 12, 2014
First decision: August 6, 2014
Revised: October 31, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: February 14, 2015
Core Tip
Core tip: Inflammatory bowel disease (IBD) in primary sclerosing cholangitis (PSC) is observed to have different characteristics in comparison with conventional IBD without PSC. Based on these differences a distinct phenotype of IBD is suspected. Existing literature was reviewed for clinical characteristics of IBD in PSC yielding 65 studies consisting of 11406 PSC-IBD patients. A large variation for reported characteristics was found, which seem to be related to case ascertainment. This emphasizes the importance of full colonoscopy and biopsies to accurately diagnose IBD in PSC. Overall however, IBD in PSC shows large differences in comparison with conventional IBD, therefore representing a distinct phenotype.