Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1804-1813
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1804
Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3
Ting Zhang, Bo Jiang, Shi-Tao Zou, Fen Liu, Dong Hua
Ting Zhang, Shi-Tao Zou, Fen Liu, Institute of Cancer, Affiliated hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China
Bo Jiang, Dong Hua, Department of Oncology, Affiliated hospital of Jiangnan University, Wuxi 214062, Jiangsu Province, China
Author contributions: Zhang T and Jiang B contributed equally to this work and should be considered as co-first authors; Jiang B and Hua D designed the research; Zhang T, Zou ST and Liu F performed the research; Zhang T analyzed the data and wrote the paper; Jiang B and Hua D revised the paper.
Supported by Project of Natural Science Foundation of Jiangsu Province, No. BK2012542; and the Project of Hospital Management Center of Wuxi City, No. YGZ1108.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dong Hua, MD, PhD, Department of Oncology, Affiliated hospital of Jiangnan University, No. 200 Huihe Road, Binhu District, Wuxi 214062, Jiangsu Province, China. wx89211@163.com
Telephone: +86-510-88682109 Fax: +86-510-85808820
Received: July 25, 2014
Peer-review started: July 26, 2014
First decision: August 27, 2014
Revised: September 19, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: February 14, 2015
Processing time: 201 Days and 6.7 Hours
Core Tip

Core tip: The expression of B7-H3 has been positively correlated with poor prognosis in colorectal cancer. Previous studies revealed the relationship between B7-H3 and tumor invasion and metastasis. In the present study, the role of B7-H3 in apoptosis in colorectal cancer was investigated. Our results showed that overexpression of B7-H3 induced resistance to apoptosis in colorectal cancer cell lines by upregulating the Jak2-STAT3 signaling pathway. These results provide a new vision for designing therapeutics targeting B7-H3 and its associated signaling pathways in the treatment of colorectal cancer.