Meta-Analysis
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1650-1662
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1650
Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index
Qing Pang, Jing-Yao Zhang, Si-Dong Song, Kai Qu, Xin-Sen Xu, Su-Shun Liu, Chang Liu
Qing Pang, Jing-Yao Zhang, Si-Dong Song, Kai Qu, Xin-Sen Xu, Su-Shun Liu, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Pang Q and Zhang JY contributed equally to this work; Pang Q participated in the research design, writing of the paper, and literature searches; Zhang JY participated in writing of the paper, literature searches, and data analysis; Song SD and Qu K participated in critical revision of the paper, and extraction and analysis of data; Xu XS and Liu SS participated in revision of the paper, and final approval; Liu C participated in the research conception and design.
Supported by National Natural Science Foundation of China, No. 30872482 and No. 81072051.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang Liu, MD, PhD, Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 277 West Yan-ta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-82653900 Fax: +86-29-82653905
Received: May 10, 2014
Peer-review started: May 10, 2014
First decision: May 29, 2014
Revised: June 11, 2014
Accepted: August 28, 2014
Article in press: August 28, 2014
Published online: February 7, 2015
Processing time: 275 Days and 16.9 Hours
Core Tip

Core tip: Central and general obesity are independently associated with increased risk of nonalcoholic fatty liver disease (NAFLD). Per-unit increase in waist circumference and body mass index increased the incidence risk of NAFLD by 0.07- and 0.25-fold, respectively. The risk for disease is increased in individuals with a higher waist circumference, waist-to-hip ratio, and body mass index by 1.34-, 3.06-, and 1.85-fold, respectively. The results of this analysis suggest that central obesity poses a greater threat to national health than general obesity. Therefore, future studies should place a greater emphasis on central obesity.