Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1518-1530
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1518
CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan
Ping Li, Xu-Dong Tang, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo
Ping Li, Zheng-Xu Cai, Juan-Juan Qiu, Xue-Lian Lin, Tong Zhu, Lawrence Owusu, Hui-Shu Guo, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Xu-Dong Tang, Department of Gastroenterology, Xi yuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
Author contributions: Li P and Tang XD contributed equally to this work, they are co-first authors; Li P, Tang XD, Cai ZX and Guo HS designed the research; Li P, Qiu JJ, Lin XL and Zhu T performed the research; Li P and Lin XL analyzed the data; Li P and Guo HS wrote the paper; Owusu L and Guo HS revised the paper.
Supported by National Natural Science Foundation of China, No. 81273919; Grants from the Natural Science Foundation of Liaoning Province, No. 2012225020 and No. 2013023002; and the National Basic Research Program of China (973 Program), No. 2013CB531703.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hui-Shu Guo, Professor, Central Laboratory, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. guohuishu1@126.com
Telephone: +86-0411-83635963 Fax: +86-411-8362-2844
Received: July 27, 2014
Peer-review started: July 28, 2014
First decision: August 6, 2014
Revised: August 28, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: February 7, 2015
Processing time: 197 Days and 3 Hours
Core Tip

Core tip: C-type natriuretic peptide (CNP) and natriuretic peptide receptor B (NPR-B) were expressed in the mucosa, muscle, and serosa of rat rectum. Expression of CNP and NPR-B are upregulated in the rectum of depressive digestive disorder rats, with the CNP/NPR-B signal pathway possibly being involved in depressive digestive disorders. Our study shows that Xiaoyaosan inhibits the expression of CNP and NPR-B in a dose-dependent manner.