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World J Gastroenterol. Dec 28, 2015; 21(48): 13418-13431
Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13418
Hepatolithiasis and intrahepatic cholangiocarcinoma: A review
Hyo Jung Kim, Jae Seon Kim, Moon Kyung Joo, Beom Jae Lee, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak
Hyo Jung Kim, Jae Seon Kim, Moon Kyung Joo, Beom Jae Lee, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak, Department of Internal Medicine, Korea University college of Medicine, Guro Hospital, Seoul 152-703, South Korea
Author contributions: Kim JS conceived and designed the review; Joo MK, Kim JH, Yeon JE and Park JJ acquired subjects and data; Byun KS and Bak YT interpreted the data; Kim HJ and Kim JS wrote the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jae Seon Kim, MD, PhD, Department of Internal Medicine, Korea University college of Medicine, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 152-703, South Korea. kimjs@kumc.or.kr
Telephone: +82-2-26261770 Fax: +82-505-1151778
Received: June 28, 2015
Peer-review started: July 2, 2015
First decision: July 20, 2015
Revised: August 11, 2015
Accepted: September 28, 2015
Article in press: September 30, 2015
Published online: December 28, 2015
Processing time: 179 Days and 8.2 Hours
Core Tip

Core tip: In this study, we review recent studies on hepatolithiasis and discuss hepatolithiasis-associated cholangiocarcinoma (HL-CCA). Management of hepatolithiasis requires proper treatment to reduce recurrence and achieve early detection of HL-CCA. It is not clear whether hepatic resection can reduce the occurrence of HL-CCA, and there is no surveillance tool to predict subsequent occurrence. Patients should be followed after treatment because there are no effective measures to prevent HL-CCA and premalignant lesions.