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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2015; 21(47): 13288-13293
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13288
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13288
Mast cell tryptase and carboxypeptidase A expression in body fluid and gastrointestinal tract associated with drug-related fatal anaphylaxis
Xiang-Jie Guo, Ying-Yuan Wang, Hao-Yue Zhang, Qian-Qian Jin, Cai-Rong Gao, Department of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Author contributions: Gao CR designed the research; Guo XJ, Wang YY, Zhang HY and Jin QQ performed the research; Guo XJ and Gao CR wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81172905; and Shanxi Province Science Foundation for Youths, No. 2012021032-2.
Institutional review board statement: All experiments were approved by the ethics committee of Shanxi Medical University.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 258187101@qq.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Cai-Rong Gao, Department of Forensic Medicine, Shanxi Medical University, No. 56 South Xinjian Road, Taiyuan 030001, Shanxi Province, China. 258187101@qq.com
Telephone: +86-351-4135175 Fax: +86-351-4135175
Received: May 24, 2015
Peer-review started: May 25, 2015
First decision: June 25, 2015
Revised: July 9, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: December 21, 2015
Processing time: 204 Days and 14.5 Hours
Peer-review started: May 25, 2015
First decision: June 25, 2015
Revised: July 9, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: December 21, 2015
Processing time: 204 Days and 14.5 Hours
Core Tip
Core tip: Drug-related fatal anaphylaxis is occasionally encountered in forensic pathology routine. However, markers in the identification of drug-related fatal anaphylaxis still need further exploration. This study identified two important markers in drug-related fatal anaphylaxis, tryptase and carboxypeptidase A, which may improve postmortem diagnosis of anaphylaxis in medicolegal expertise.