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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2015; 21(47): 13268-13276
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13268
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13268
Potential roles of EZH2, Bmi-1 and miR-203 in cell proliferation and invasion in hepatocellular carcinoma cell line Hep3B
Fang Yang, Li-Zhi Lv, Qiu-Cheng Cai, Yi Jiang, Department of Hepatobiliary Surgery, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350025, Fujian Province, China
Author contributions: Yang F contributed new reagents and analytic tools, and analyzed the data; Lv LZ conducted the experimental work; Cai QC participated in the manuscript drafting work; Jiang Y designed the research.
Institutional review board statement: All study protocols were approved by the Ethics Committee for Clinical Research of Fuzhou General Hospital.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi Jiang, PhD, Department of Hepatobiliary Surgery, Fuzong Clinical Medical College of Fujian Medical University, No. 156 Xierhuan North Road, Fuzhou 350025, Fujian Province, China. jiangyi8183@163.com
Telephone: +86-591-22859377 Fax: +86-591-22859377
Received: January 10, 2015
Peer-review started: January 10, 2015
First decision: March 10, 2015
Revised: May 3, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: December 21, 2015
Processing time: 338 Days and 14.2 Hours
Peer-review started: January 10, 2015
First decision: March 10, 2015
Revised: May 3, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: December 21, 2015
Processing time: 338 Days and 14.2 Hours
Core Tip
Core tip: In this study, we analyzed the expression levels of Bmi-1, EZH2, and miR-203 in hepatocellular carcinoma (HCC) tissues and in Hep3B cell line. Comprehensive experimental methods were used to investigate the roles of Bmi-1, EZH2, and miR-203 in Hep3B cell proliferation, invasion and apoptosis. This study aimed to investigate the potential collaborate regulation mechanism of EZH2, Bmi-1, and miR-203 in metastasis and invasion of HCC.