Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2015; 21(46): 13073-13079
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13073
Seven-day triple therapy is a better choice for Helicobacter pylori eradication in regions with low antibiotic resistance
Yue-Feng Tong, Jun Lv, Li-Yuan Ying, Fang Xu, Bo Qin, Ming-Tong Chen, Fei Meng, Miao-Ying Tu, Ning-Min Yang, You-Ming Li, Jian-Zhong Zhang
Yue-Feng Tong, Jun Lv, Li-Yuan Ying, Fang Xu, Bo Qin, Ming-Tong Chen, Department of Gastroenterology, The First People’s Hospital of Yongkang, Yongkang 321300, Zhejiang Province, China
Fei Meng, Miao-Ying Tu, Department of Research Service, Zhiyuan Inspection Medical Institute, Hangzhou 310030, Zhejiang Province, China
Ning-Min Yang, Department of Clinical Laboratory, Zhiyuan Medical Inspection Institute CO., LTD, Hangzhou 310030, Zhejiang Province, China
You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China
Jian-Zhong Zhang, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Jian-Zhong Zhang, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310030, Zhejiang Province, China
Author contributions: Tong YF, Li YM and Zhang JZ formulated the problem; Lv J, Ying LY, Xu F, Qin B and Chen MT collected the samples and designed the treatments; Ying LY, Xu F and Chen MT participated in the follow-up of cases; Tu MY and Yang NM performed Helicobacter pylori isolations and antibiotic susceptibility tests; Tong YF and Meng F analyzed the data and wrote the paper.
Supported by Science and Technology Program of Zhejiang Province, China, No. 2001C23140; National Technology R and D Program in the 12th Five-Year Plan of China, No. 2012BAI06B02; Major Technology Project as part of “Prevention and Control of Major Infectious Diseases including AIDS and Viral Hepatitis”, No. 2013ZX10004216-002; and National Key Scientific Instrument and Equipment Development Project, No. 2012YQ180117.
Institutional review board statement: This study was approved by the Ethics Committee of the National Institute for Communicable Disease Control and Prevention.
Conflict-of-interest statement: To the best of our knowledge, no conflicts of interest exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Zhong Zhang, MD, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping District, Beijing 102206, China. zhangjianzhong@icdc.cn
Telephone: +86-10-61739456 Fax: +86-10-61739439
Received: May 21, 2015
Peer-review started: May 23, 2015
First decision: August 26, 2015
Revised: September 10, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: December 14, 2015
Processing time: 201 Days and 23.8 Hours
Core Tip

Core tip: A major cause of treatment failure for Helicobacter pylori (H. pylori) infections is the increasing rate of antibiotic resistance. A total of 1106 H. pylori-positive patients were treated with one of three types of 7-d triple therapies. The results of the 13C-urea breath test during patient follow-up indicated that the eradication rates were greater than 90%. The susceptibility of all H. pylori strains to four antibiotics was determined using an agar-dilution method. We found that the eradication rate was significantly different in antibiotic-resistant patients. In populations with low levels of resistance, 7-d triple therapy is a better choice.