Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2015; 21(46): 13030-13041
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13030
Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1
Weiqi Tan, Seng-Gee Lim, Theresa MC Tan
Weiqi Tan, Theresa MC Tan, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore S117597, Singapore
Seng-Gee Lim, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore S117597, Singapore
Author contributions: Tan W performed the experiments; Lim SG contributed to the hepatocellular carcinoma data; Tan W and Tan TMC wrote the paper.
Supported by Biomedical Research Council and Ministry of Education (Tier 1) awarded to Tan TM.
Institutional review board statement: The study was reviewed and approved by the National Health Group Domain Specific Review Board.
Institutional animal care and use committee statement: This is not applicable. No animal was used for this study.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Theresa MC Tan, Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sg
Telephone: +65-65163685 Fax: +65-67791453
Received: May 22, 2015
Peer-review started: May 23, 2015
First decision: July 19, 2015
Revised: September 10, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: December 14, 2015
Processing time: 201 Days and 6.7 Hours
Core Tip

Core tip: In this study, miR-210 is significantly up-regulated in hepatocellular carcinoma (HCC). Over-expression of miR-210 decreased cell proliferation and delayed cell cycle progression of HCC cells. The tyrosine kinase Yes1 is shown to be a target of miR-210 and is down-regulated in HCC. Knock-down of Yes1 by siRNA also significantly reduced cell proliferation. These results increase the understanding of the multiple roles of miR-210 in liver cancer growth and metastasis.