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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
Manuel A Valenzuela, Jimena Canales, Alejandro H Corvalán, Andrew FG Quest
Manuel A Valenzuela, Jimena Canales, Andrew FG Quest, Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula, Programa de Biología Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile
Manuel A Valenzuela, Jimena Canales, Alejandro H Corvalán, Andrew FG Quest, Cellular Communication Laboratory, Center for Molecular Studies of the Cell, Advanced Center for Chronic Diseases, School of Medicine, Universidad de Chile, Santiago 8380453, Chile
Alejandro H Corvalán, UC - Centro de Investigación en Oncología, Pontificia Universidad Católica de Chile, Santiago 8330034, Chile
Alejandro H Corvalán, Departamento de Hematología-Oncología, Facultad de Medicine, Pontificia Universidad Católica de Chile, Santiago 8330074, Chile
Author contributions: Valenzuela MA and Quest AFG wrote and edited the review, designed its structure and made conceptual revisions of the different sections; Canales J contributed with a bibliographic revision and discussion in the section “Genes modified by methylation upon H. pylori infection”, and also designed Figure 1; Corvalán AH contributed with the discussion in the section “Reprimo as a model for epigenetic changes in tumor suppressor genes in gastric cancer” and the clinical findings concerning miRNA biology.
Supported by CONICYT-FONDAP project, No. 15130011 (to Corvalánand AH and Quest AFG); FONDECYT project, No. 1151411 (to Corvalán AH); and a CONICYT PhD fellowship award (to Canales J).
Conflict-of-interest statement: Authors declare no conflict of interests for this article
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Andrew FG Quest, PhD, Cellular Communication Laboratory, Center for Molecular Studies of the Cell, Advanced Center for Chronic Diseases, School of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile. aquest@med.uchile.cl
Telephone: +56-2-27382015 Fax: +56-2-27382015
Received: May 27, 2015
Peer-review started: May 29, 2015
First decision: July 14, 2015
Revised: August 8, 2015
Accepted: October 13, 2015
Article in press: October 13, 2015
Published online: December 7, 2015
