Monaco S, Mariotto S, Ferrari S, Calabrese M, Zanusso G, Gajofatto A, Sansonno D, Dammacco F. Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015. World J Gastroenterol 2015; 21(42): 11974-11983 [PMID: 26576086 DOI: 10.3748/wjg.v21.i42.11974]
Corresponding Author of This Article
Salvatore Monaco, MD, Professor, Department of Neurological and Movement Sciences, University of Verona, Policlinico “G.B. Rossi”, Piazzale L.A. Scuro 10, 37134 Verona, Italy. salvatore.monaco@univr.it
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 14, 2015; 21(42): 11974-11983 Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.11974
Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015
Salvatore Monaco, Sara Mariotto, Sergio Ferrari, Massimiliano Calabrese, Gianluigi Zanusso, Alberto Gajofatto, Domenico Sansonno, Franco Dammacco
Salvatore Monaco, Sara Mariotto, Sergio Ferrari, Massimiliano Calabrese, Gianluigi Zanusso, Alberto Gaiofatto, Department of Neurological and Movement Sciences, University of Verona, 37134 Verona, Italy
Domenico Sansonno, Franco Dammacco, Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, Italy
Author contributions: Monaco S, Mariotto S, Sansonno D and Dammacco F conceived and designed the manuscript; Ferrari S, Calabrese M, Zanusso G and Gajofatto A performed the literature review; all authors wrote and approved the final version of the manuscript.
Supported by Ministero della Salute, Italy, No. RF-2011-02347955 to Monaco S.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Salvatore Monaco, MD, Professor, Department of Neurological and Movement Sciences, University of Verona, Policlinico “G.B. Rossi”, Piazzale L.A. Scuro 10, 37134 Verona, Italy. salvatore.monaco@univr.it
Telephone: +39-45-8124768 Fax: +39-45-8027492
Received: June 3, 2015 Peer-review started: June 6, 2015 First decision: August 31, 2015 Revised: September 11, 2015 Accepted: September 30, 2015 Article in press: September 30, 2015 Published online: November 14, 2015 Processing time: 160 Days and 18.2 Hours
Core Tip
Core tip: Neurocognitive dysfunction, sleep disturbance, depression, fatigue and reduced quality of life are common manifestations of chronic hepatitis C virus (HCV) infection. Neuropsychological performance is impaired in HCV patients, in the absence of structural brain alterations on conventional magnetic resonance imaging (MRI). Brain metabolic and microstructural changes are easily detected by in vivo proton magnetic resonance spectroscopy and perfusion-weighted/diffusion tensor MRI, enabling detection of brain dysfunction in clinically asymptomatic subjects. The regional distribution of metabolic changes indicates an exclusive involvement of telencephalic areas, but not the diencephalon or brainstem. HCV is likely to play a major pathogenic role in these disorders.
