Sokic-Milutinovic A, Alempijevic T, Milosavljevic T. Role of Helicobacter pylori infection in gastric carcinogenesis: Current knowledge and future directions. World J Gastroenterol 2015; 21(41): 11654-11672 [PMID: 26556993 DOI: 10.3748/wjg.v21.i41.11654]
Corresponding Author of This Article
Aleksandra Sokic-Milutinovic, MD, PhD, Professor, Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia and School of Medicine University of Belgrade, Koste Todorovica 6, 11000 Belgrade, Serbia. asokicmilutinovic@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 7, 2015; 21(41): 11654-11672 Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11654
Role of Helicobacter pylori infection in gastric carcinogenesis: Current knowledge and future directions
Aleksandra Sokic-Milutinovic, Tamara Alempijevic, Tomica Milosavljevic
Aleksandra Sokic-Milutinovic, Tamara Alempijevic, Tomica Milosavljevic, Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia and School of Medicine University of Belgrade, 11000 Belgrade, Serbia
Author contributions: Sokic-Milutinovic A, Alempijevic T and Milosavljevic T did literature research and wrote the paper; and Sokic-Milutinovic A approved final version of the manuscript.
Conflict-of-interest statement: Authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Aleksandra Sokic-Milutinovic, MD, PhD, Professor, Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia and School of Medicine University of Belgrade, Koste Todorovica 6, 11000 Belgrade, Serbia. asokicmilutinovic@gmail.com
Telephone: +381-11-3663734 Fax: +381-11-3615432
Received: May 21, 2015 Peer-review started: May 22, 2015 First decision: June 23, 2015 Revised: July 16, 2015 Accepted: September 22, 2015 Article in press: September 22, 2015 Published online: November 7, 2015 Processing time: 166 Days and 12.7 Hours
Core Tip
Core tip: Two main therapeutic strategies could reduce the incidence of Helicobacter pylori (H. pylori)-related gastric cancer: eradication of the infection or vaccination. Success of a gastric cancer prevention strategy depends on the eradication of the infection or on vaccination before irreversible mucosal changes (severe atrophy, intestinal metaplasia or dysplasia) have occurred. Eradication therapy results are suboptimal due to increased antibiotic resistance in H. pylori and patient noncompliance. To improve the rates of eradication, rescue regimens have been developed. Concomitant and sequential protocols seem equally effective rescue strategies. An effective vaccine is not available at present, in spite of enormous effort by different researchers.
