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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2015; 21(41): 11522-11541
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11522
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11522
Inflammatory status in human hepatic cirrhosis
María Martínez-Esparza, María Tristán-Manzano, Antonio J Ruiz-Alcaraz, Pilar García-Peñarrubia, Departamento de Bioquímica, Biología Molecular (B) e Inmunología, Facultad de Medicina, IMIB, Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, 30100 Murcia, Spain
Author contributions: Martínez-Esparza M contributed to study design, literature search, manuscript writing, figure design and final revision of the manuscript; Tristán-Manzano M contributed to the writing, figure design and final revision of the manuscript; Ruiz-Alcaraz AJ contributed to the writing, and final revision of the manuscript; García-Peñarrubia P contributed to study design, literature search, manuscript writing and final revision of the manuscript.
Supported by Grant 11926/PI/09 from the Fundación Séneca, Comunidad Autónoma de la Región de Murcia, Spain.
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: María Martínez-Esparza, PhD, Professor in Immunology, Departamento de Bioquímica, Biología Molecular (B) e Inmunología, Facultad de Medicina, IMIB, Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, 30100 Murcia, Spain. maria@um.es
Telephone: +34-868-883989 Fax: +34-868-888601
Received: June 26, 2015
Peer-review started: June 29, 2015
First decision: July 13, 2015
Revised: July 31, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: November 7, 2015
Peer-review started: June 29, 2015
First decision: July 13, 2015
Revised: July 31, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: November 7, 2015
Core Tip
Core tip: This review focuses on new findings about the inflammatory status involved in the development of human liver cirrhosis, avoiding results obtained from animal models. Liver cirrhosis is induced by the two main causes, infection with hepatitis C virus and chronic alcohol abuse. Detecting differences in the inflammatory status between both cirrhosis etiologies could be useful to identify specific targets for preventive and therapeutic intervention in each case.